PT-141

Bremelanotide · Vyleesi

A melanocortin receptor agonist approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women.

FDA approved. Approved or legitimately prescribed for at least one indication. Dose information below is reference material, not a recommendation — follow your prescriber and the product labelling.

At a glance

Category: Sexual Health
Half-life: ~2.7 hours
Typical vial sizes: 5 mg · 10 mg
Commonly cited dose: 500–1750 mcg
Frequency: as needed, not more than once daily
Routes: Subcutaneous · Intranasal

A 5 mg vial, worked through.

Reconstituting a 5 mg vial of PT-141 with 2 mL of bacteriostatic water gives 2.5 mg/mL. A 500 mcg dose is then:

20units(0.2 mL) — about 10 doses per vial

Storage

Lyophilised (unmixed): Refrigerated, protected from light.
Reconstituted: Refrigerate at 2–8°C.

What people log it against

Outcomes users commonly track alongside this compound. Listing them is not a claim that it produces them.

Libido tracking (approved indication for Vyleesi)

Read alongside PT-141

Compounds this one is commonly compared with, combined with, or mistaken for. Listing a pairing is not a suggestion to run them together.

Kisspeptin-10Research use onlyBoth touch sexual function through unrelated pathways: PT-141 acts centrally on melanocortin receptors, kisspeptin upstream of the HPG axis.

References

Each source below establishes only the specific claim noted with it, last checked 2026-08-13. Dose ranges, frequencies and storage times reflect what circulating protocols commonly state and are not established by these references.

FDA label — VYLEESI (bremelanotide), DailyMed
"mean terminal half-life of bremelanotide is approximately 2.7 hours (range: 1.9-4.0 hours)" after single subcutaneous administration — confirms halfLifeHours 2.7.

Run your own numbers

Pick PT-141 from the preset list to start from a typical vial.

Your vial

Peptide in vial

As printed on the vial label

Bacteriostatic water added

How much you inject into the vial

Dose you want

mcg

1000 mcg = 1 mg

Syringe size

Start from a peptide

Fills in a common vial size and the low end of commonly cited protocols. Always check against your own vial.

Draw this much

5units

on a 1 mL U-100 insulin syringe

Concentration: 5 mg/mL
Volume: 0.05 mL
Doses in this vial: 40

Keep this vial. VialPal holds the concentration, counts down the doses left in it, and logs the ones you actually took.

VialPal does the arithmetic — it does not tell you what to take. Dose decisions belong between you and a qualified clinician.