Semaglutide
A long-acting GLP-1 receptor agonist approved for type 2 diabetes and chronic weight management.
Part of the GLP-1 medicines reference: how this compares with the other GLP-1 drugs, and what the FDA says about compounded versions.
At a glance
- Category
- Metabolic
- Half-life
- ~7 days
- Typical vial sizes
- 2 mg · 5 mg · 10 mg
Concentration by water volume
Pure arithmetic: the vial strength divided by the water added. The dose itself comes from your clinician, pharmacy, product instructions, or research protocol — enter it in the calculator below.
| Vial | Water added | Concentration | Per U-100 unit |
|---|---|---|---|
| 2 mg | 1 mL | 2 mg/mL | 20 mcg |
| 2 mg | 2 mL | 1 mg/mL | 10 mcg |
| 2 mg | 3 mL | 0.667 mg/mL | 6.667 mcg |
| 5 mg | 1 mL | 5 mg/mL | 50 mcg |
| 5 mg | 2 mL | 2.5 mg/mL | 25 mcg |
| 5 mg | 3 mL | 1.667 mg/mL | 16.667 mcg |
| 10 mg | 1 mL | 10 mg/mL | 100 mcg |
| 10 mg | 2 mL | 5 mg/mL | 50 mcg |
| 10 mg | 3 mL | 3.333 mg/mL | 33.333 mcg |
Storage
- Lyophilised (unmixed)
- Refrigerated.
- Reconstituted
- Refrigerate at 2–8°C. Follow compounding pharmacy guidance.
What people log it against
Outcomes users commonly track alongside this compound. Listing them is not a claim that it produces them.
- Weight management
- Glycaemic control
- Appetite tracking
Read alongside Semaglutide
Compounds this one is commonly compared with or mistaken for. Listing a pairing is not a suggestion to use them together.
- TirzepatideFDA-approved product existsThe two most-compared incretin agonists: semaglutide targets GLP-1 alone, tirzepatide is a dual GLP-1/GIP agonist.
- AOD-9604Research use onlyBoth come up in weight-management discussions, but AOD-9604 is a growth-hormone fragment rather than an incretin agonist, and its evidence base is far thinner.
References
Each source below establishes only the specific claim noted with it, last checked 2026-08-13. Storage times reflect common handling guidance and are not established by these references.
- FDA label — WEGOVY (semaglutide), DailyMed
"an elimination half-life of approximately 1 week" — confirms the 168-hour half-life used here. Label also notes semaglutide remains in circulation ~5-7 weeks after the last dose.
Run your own numbers
Enter the dose and concentration from your clinician, pharmacy, product instructions, or research protocol. VialPal handles the math.
As printed on the vial label
How much water you add to the vial
From your clinician, pharmacy, product instructions, or research protocol. 1000 mcg = 1 mg
Fills in a vial size this compound is commonly sold in. It does not fill in a dose — check the size against your own vial label.
Enter your numbers
Still needed: vial strength, bacteriostatic water, dose. Use the figures on your vial label and the dose from your clinician, pharmacy, product instructions, or research protocol — VialPal handles the math.
Keep this vial. VialPal holds the concentration, counts down the doses left in it, and logs the ones you actually took.
Get VialPalVialPal does the arithmetic — it does not tell you what to take. Dose decisions belong between you and a qualified clinician.